Horses face a wide array of abuse, neglect, and exploitation including horse racing, stable confinement, cruel sports training, horse-drawn carriages, horse riding, raising them for meat, using them for tourist treks, pony rides, using horses as working animals on city streets, injecting them with a toxin and harvesting their antibodies, and rodeo events and training.

The drug Premarin is made by continually impregnating horses and confining them to tight stalls 24/7 while hooked to a machine to collect their urine. They are unable to turn around or lay down. Horses are sociable creatures, designed by evolution to spend most of their time grazing in a natural setting. Horses develop stereotypic behaviors and other problems when kept in isolation, unable to graze, or if subjected to prolonged confinement in a stable.